The itch wakes you at 3am because your natural steroid hits its lowest.
Ever notice you fall asleep fine, then wake up at 3am scratching?
Your body makes its own steroid, called cortisol. In the early hours, it drops to its lowest. Nothing is holding the itch back.
The steroid cream you put on at 10pm only sits on your skin. This itch is coming from inside.
That's why SpiroPlus is taken before bed. Its blue spirulina supports a calmer response through those hours.
Source: Patel et al., Acta Dermato-Venereologica, 2007.
Less going on inside at night. Less itch to wake you up.